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LOS ANGELES (AP) ? Cleanthony Early kept stealing glances down at the hat in his hands while he waited for his turn to climb the stepladder. The Wichita State forward seemed stunned at the words on the side of his brand-new ballcap: "Final Four Atlanta."

"It's crazy. I still can't believe we're here," Early said. "You try to expect it, but you expect a lot of things that don't happen. This really happened."

Believe it. Wichita State is going to Atlanta, and these Shockers are no longer a surprise after the way the tenacious ninth seeds held off mighty Ohio State in the West Regional final.

Malcolm Armstead scored 14 points, Fred Van Vleet bounced in a big basket with 1 minute left, and Wichita State earned its first trip to the Final Four since 1965 with a 70-66 victory over the Buckeyes on Saturday.

Van Vleet scored 12 points as the Shockers (30-8) followed up last week's win over top-ranked Gonzaga with a nail-biting victory over the second-seeded Buckeyes (29-8), whose 11-game winning streak ended one short of their second straight Final Four. Wichita State's 20-point lead in the second half dwindled to three in the final minutes, but several Shockers stepped up with big plays to stop the surge, heeding coach Gregg Marshall's halftime command to "play angry."

All that anger turned into a joyous postgame party at midcourt, even though the Shockers realize they've got more work to do.

"I don't think we're Cinderella at all," Marshall said. "Cinderellas usually are done by this stage. If you get to this point, you can win the whole thing. You beat a No. 1 seed and a No. 2 seed ? I don't think Cinderella just found one glass slipper. I think she found four."

Wichita State is just the fifth team seeded ninth or higher to reach the Final Four since seeding began in 1979, but the second in three years following 11th-seeded VCU's improbable run in 2011. The Shockers' celebration was wild, if a bit disbelieving, in front of several thousand roaring fans.

"Last year we were watching all this on television," said Early, who scored 12 points despite spraining his ankle in the second half. "I just feel like we've got the same potential as those (big-name) guys, regardless if they know who we are or not. We just tend to work hard."

Wichita State roared to a 20-point lead with 11 minutes to play after Ohio State played an awful first half, but LaQuinton Ross scored 15 of his 19 points after halftime, leading a ferocious rally that got the Buckeyes within three points in the final minutes.

Tekele Cotton hit a clutch 3-pointer for Wichita State with 2:20 left and grabbed a key offensive rebound moments later, allowing VanVleet to score on a shot that bounced all over the rim before dropping. Ron Baker and Cotton hit last-minute free throws to secure the second Final Four trip in Wichita State's history and a school-record 30th win.

"We're happy, but I'm still shocked," said Carl Hall, the glasses-wearing big man who scored eight points and led the Shockers' strong defensive effort. "We've got a team full of fighters. I brought them all together near the end and said, 'No matter what happens, I love y'all.' We had to fight so hard. We've got each other's backs, and it's hard to beat a team that's got five guys who work together like us."

Deshaun Thomas scored 21 points after missing nine of his first 12 shots for Ohio State, which made just 24 percent of its first-half shots. Aaron Craft scored nine points on 2-for-12 shooting against Armstead and a host of defenders for the Buckeyes, who dug a hole too deep to escape with their second-half rally.

"The way we shot coming into the Sweet 16, Elite Eight, everything was falling," Thomas said. "Today, it just wasn't our night. Nothing was falling. We had great looks, some of them, but they just weren't falling."

Yet after two weeks of upsets in the wild West bracket, underdog Wichita State seemed an appropriate pick to cut down Staples Center's nets. The Shockers' well-balanced roster managed built that enormous lead with the same consummate team play that they've shown throughout the tournament.

The Shockers are also the kings of Kansas, reaching the national semifinals after the powerful Jayhawks and Kansas State both went down.

Two sections packed with cheering Shockers fans provided all the encouragement necessary for a team that didn't win the Missouri Valley Conference tournament and was thought to be a bubble team for an NCAA berth. Now, Wichita State is the MVC's first Final Four team since Larry Bird led Indiana State to the title game in 1979.

Another giant awaits the Shockers in Atlanta next weekend: They'll face the winner of Sunday's Midwest Regional final between Duke and Louisville.

"We're all new to this, but I think we're ready for this," Early said. "We're going to prepare ourselves, and this game was pretty good preparation. We started at the bottom, and we've been working our way up."

Everybody chipped in for the Shockers. Armstead, the Oregon transfer, was named the regional's top player. Baker made nine free throws without a miss on his 20th birthday. And both Early and Hall returned to the court with second-half injuries, pushing Wichita State forward.

Seven seasons after underdog George Mason crashed the Final Four and underlined college basketball's growing parity, the Shockers are the latest smallish school to get on a big roll in the tournament. Butler made the national championship game in 2010 and 2011, and the Bulldogs were joined by that VCU team in the Final Four two years ago.

This year's tournament included stunning wins by Florida Gulf Coast, La Salle and Harvard, but nobody kept it going longer than Wichita State.

Although the Shockers have a beautiful home arena and robust support from fans and donors in Kansas' largest city, Marshall acknowledged that Wichita State's athletic budget is a fraction of what a BCS school can spend. He hasn't let it slow the Shockers, who made the NCAA tournament last year only to lose to 12th-seeded VCU in the first round.

After the Shockers easily beat La Salle two days ago to reach their first regional final since 1981, Marshall's pregame speech to the Shockers on Saturday finished with talk of cutting down the nets at Staples Center before getting on that plane back to Kansas, saying Wichita State didn't have to play "a perfect game" to beat mighty Ohio State.

"The Mecca awaits in Atlanta," he said.

Marshall was right, but he couldn't have anticipated just how imperfect Ohio State would be.

The postseason-tested Buckeyes appeared calm and confident during warmups in front of their healthy fan contingent, yet they proceeded to play the first half just like NCAA newbies.

They missed their first seven shots after the opening tip in a string capped by an airballed 3-pointer from Thomas, who missed his first five overall. The junior star was labeled "a bad-shot taker and a bad-shot maker" by Marshall on Friday, but he only lived up to the first part of that billing while going 4 for 13 in the first half.

Early hit two 3-pointers in the opening minutes, and the Shockers stretched their lead to 13 points shortly before halftime.

"You've got to give them credit," Craft said. "They really came out firing and we really didn't regain our footing until it was too late."

Hall went to the locker room after drawing a charge from Thomas early in the second half, holding the back of his head after Thomas' elbow clipped him on the jaw. Hall found his glasses and got back in the game 66 seconds later.

Wichita State gradually stretched its lead early in the second half, with Early's layup putting the Shockers up 53-33 with 12:09 to play.

Ross desperately tried to rally the Buckeyes, scoring eight consecutive points and leading a 23-6 run midway through the second half. Ohio State went into a full-court inbounds defense, and Shannon Scott's free throws with 2:49 left cut the lead to 62-59 ? but Ohio State couldn't get any closer.

Source: http://news.yahoo.com/wichita-state-upsets-osu-70-66-final-four-014501269--spt.html

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MONTGOMERY, Ala. (AP) ? Former Alabama athletic director Mal Moore, who played and coached under Bear Bryant, hired Nick Saban and presided over a heyday in athletics at his alma mater, has passed away.

The university said the 73-year-old Moore died on Saturday at Duke University Medical Center. Moore had been in the Durham, N.C., hospital since March 13 with pulmonary problems.

The folksy, silver-haired Moore was part of 10 football national championship teams as a player, coach or administrator in a career intertwined with three of the Crimson Tide's most revered coaches ? his old bosses Bryant and Gene Stallings and Saban, who has won three of the last four national titles.

He played for Bryant's 1961 national championship team, and Bill Battle ? another member of that team ? was hired to replace him two days after Moore stepped down on March 20. He was to become a special advisor to Alabama President Judy Bonner.

"The University of Alabama and the world of intercollegiate athletics have lost a legend, and I have lost a dear friend," Battle said in a statement. "My heart goes out to his family and close friends in this time of sadness. After a time of grieving, we can begin to celebrate Mal's life, as his legacy will last for generations."

Moore oversaw an athletic department since 1999 that made more than $240 million in facilities improvements ? including multiple expansions of Bryant-Denny Stadium ? and won national championships in football, gymnastics, softball and women's golf in 2011-12.

He hired Saban in January 2007 after flying to south Florida hoping to lure him from the NFL's Miami Dolphins.

"Mal was truly a special person in every sense of the word," the coach said. "We can talk about all the championships Mal has been involved with, but I think what will be remembered most was the man he was. He always put the best interests of others ahead of his own, he carried himself as a first-class gentleman, and he helped bring out the best in those around him.

"Mal was an outstanding leader in terms of all he did for Alabama athletics. Most importantly, he was a great friend to me and my family. Mal was the number one reason we decided to make the move to Tuscaloosa."

The football building and his own memorabilia-covered office were housed in the Mal M. Moore Athletic Facility, named after him in 2007.

"Coach Moore will be deeply missed," said Gov. Robert Bentley, a 1964 Alabama graduate. "I've known Mal for over 30 years and have always considered him a good friend as well as a good man. He was devoted to UA athletics, and he will also be remembered for his dedication to his family. Mal made a positive impact on our entire state."

Moore's biggest claims to fame might have been the hiring of Saban and his long relationship with Bryant, whom he had hoped to succeed.

He also helped Bryant switch to the wishbone offense in 1971

"I think my first reaction would be that he will go down in the annals of the University of Alabama football program as truly one of the seminal figures that have ever been," longtime Birmingham radio talk show host Paul Finebaum said. "You hear this line sometimes and it's perceived as a cliche ? but if there was a Mount Rushmore for Alabama football, I really think coach Moore would be right next to coach Bryant. I think he was that important.

"I don't think anybody has affected Alabama football longer than Mal, when you consider when he got there, what he's done and the legacy he leaves behind."

Finebaum said he introduced Moore at a January event and told Moore: "Mal, you're going to be remembered as the man who hired Nick Saban."

"He just laughed and broke out in that toothy grin," Finebaum said. "He loved that. He loved nothing more than the University of Alabama."

Moore was a freshman on Bryant's first Alabama team in 1958 then spent 22 seasons as a coach, including a stint with Stallings for the NFL's Cardinals in St. Louis and Phoenix.

He joined Bryant as a graduate assistant in 1964 and coached both the secondary and quarterbacks before becoming the Tide's first offensive coordinator in 1975. He was also Stallings' offensive coordinator from 1990-93 in a tenure that included the 1992 national championship.

"You've got to realize he's got 10 national championship rings," Stallings said. "Not many people have done that. He was responsible for hiring Coach Saban, which obviously has really made a difference in the program. All of those great facilities ? the expansion on the stadium, the (luxury) boxes, the expansion of the complex ? fell under his responsibility.

"Coach Bryant was very fond of Mal Moore. In fact, he used to tell me from time to time, 'I'm telling you, Mal Moore is as good a football coach as you are.' He had great respect for Mal."

Moore interviewed to take over the program after Bryant retired in 1982 but was passed over in favor of New York Giants coach Ray Perkins. That left Moore thinking about getting out of the profession before Notre Dame's Gerry Faust hired him to coach running backs.

"At the time, I kind of felt like a man without a country," Moore said in a December 2012 interview ahead of the BCS championship game with the Fighting Irish. "I was in a strange position that I'd never been in before."

His wife of 41 years, the former Charlotte Davis, passed away after a long illness in 2010. His daughter, Heather Cook, lives in Scottsdale, Ariz.

Auburn athletic director Jay Jacobs said Moore "served his alma mater with grace and dignity."

Southeastern Conference Commissioner Mike Slive remembered Moore similarly.

"It was with great sadness that we learned our dear friend Mal Moore passed away this morning," Slive said. "Mal was a dignified and quiet man, always charming, gracious, thoughtful and caring. Mal had a wonderful sense of humor and was a great storyteller, while at all times a man of abiding humility. He was a loving and devoted husband, father and grandfather. He will be missed by all of us."

Several current Tide players responded to the news of Moore's passing on social media.

"Coach Mal Moore will be missed so much," quarterback AJ McCarron said on his Twitter page. "I love you coach & know you will be watching over us from above. We will always remember you (hash)loveU".

Safety Vinnie Sunseri posted on Twitter: "Thank you for everything you've done for this entire University Coach Moore your a inspiration to us all and even more u were a great man!"

Source: http://news.yahoo.com/longtime-alabama-ad-mal-moore-passes-away-184153833--spt.html

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jukkanmukkir · 31 March 2013

31 March 2013 Last updated at 03:17 ET

Five members of the South African military have died in a helicopter crash, officials said.

The aircraft was patrolling the Kruger National Park on Saturday evening looking for rhino poachers.

The patrol was routine and an investigation is under way.

The poaching of rhinos is rampant in South Africa. Their horns are sold in Asia, where some believe they have medicinal purposes, although there is no evidence to support it.

The South African Broadcasting Corporation quoted Brig Gen Xolani Mabanga as saying that the Agusta A1-0-9 light utility helicopter had come down at around 19:00 GMT on Saturday, killing all five people on board.

Gen Mabanga said the ministry of defence extended condolences to the families of the deceased, all members of the South African National Defence Force.

Source: http://www.bbc.co.uk/news/world-africa-21986456#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Sandrine Ceurstemont, editor, New Scientist TV

Lobsters have to be really hungry to prey on sea hares. When provoked, the animals unleash an unusual weapon, squirting predators with purple ink and sticky goo that knocks out their sense of smell (see video above).

Releasing ink is a common deterrent, thought to cloak prey so they can escape from an attacker, but how the additional sticky secretion works has been a mystery. Now Charles Derby from Georgia State University in Atlanta and colleagues have conducted the first experiments that reveal how it incapacitates predators, making them unable to sniff out prey.

To test whether the goo physically blocks a predator's sense of smell or uses chemicals to affect it, the team extracted the sticky component and painted it onto the tips of lobster antennae, which contain smell sensors. When the treated crustaceans were tempted with shrimp juice, the team found that the electrical activity in their sensory and motor neurons was greatly reduced. But when their antennae were gunk-free, or coated with the chemical attractants in the goo, their neurons fired when presented with prawn snacks.

The experiments prove that the stickiness of the goo is key to the defensive effect, physically plugging smell receptors. It's the first time a demo has uncovered a defence mechanism that knocks out one of a predator's senses.

If you enjoyed this post, see how frog embryos listen out for bad vibrations to avoid snakes or watch how slime secretions make hagfish hard to bite.

Journal reference: The Journal of Experimental Biology, DOI: 10.1242/jeb.081828

Source: http://feeds.newscientist.com/c/749/f/10897/s/2a179f4f/l/0L0Snewscientist0N0Cblogs0Cnstv0C20A130C0A30Csea0Ehare0Esticky0Egoo0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm

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jukkanmukkir · March 28, 2013

Associated Press Sports

updated 10:07 a.m. ET March 28, 2013

JERUSALEM (AP) -Israeli police have arrested a Congolese footballer with Maccabi Netanya in connection with the killing of a 20-year-old Israeli woman.

Police spokeswoman Luba Samri says the player and another unnamed Congo-born man were brought before a court on Thursday on suspicion of involvement with the woman's death. The court has barred publication of the player's name.

The woman's body was found on Wednesday, sprawled on a railing at the foot of a hotel in Netanya, north of Tel Aviv, where the two suspects were living.

Samri says initial autopsy results suggest the woman was killed. She said the player is under house arrest and will undergo further questioning on Friday.

A lawyer for the player told the YNet website the player denies involvement in her death.

More news

If World Cup draw was today ...

PST: We took the current standings from qualifying tournaments around the world, assumed the teams? points-per-game rates played out, and then ?qualified? the appropriate teams for Brazil.

Source: http://nbcsports.msnbc.com/id/51361580/ns/sports-soccer/

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TORONTO (AP) ? Research In Motion Ltd. said Thursday that it sold about 1 million of its critically important new BlackBerry 10 devices and returned to profitability in the most recent quarter.

The earnings provide a first glimpse of how RIM's new touch-screen Z10 is selling internationally and in Canada since its debut Jan. 31. Details on the U.S. launch are not part of the fiscal fourth quarter's financial results because the Z10 just went on sale in the U.S. last week.

In the quarter that ended March 2, RIM earned $98 million, or 19 cents a share, compared with a loss of $125 million, or 24 cents a share, a year earlier. Revenue fell 36 percent to $2.7 billion, from $4.2 billion. Analysts surveyed by FactSet had expected $2.82 billion.

"I thought they were dead. This is a huge turnaround," Jefferies analyst Peter Misek said from New York.

Misek said the Canadian company "demolished" the numbers, especially its gross margins. RIM reported gross margins of 40 percent, up from 34 percent a year earlier. The company credited higher average selling prices and higher margins for devices.

"This is a really, really good result," Misek said. "It's off to a good start."

Chief executive Thorsten Heins said he implemented numerous changes at the company over the past year and those changes have resulted in RIM returning to profitability.

The company also announced that co-founder Mike Lazaridis will retire as vice chairman and director.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-28-CN-Earns-Research-In-Motion/id-78086b3f1741495eb25b9dbe7c484f03

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What's YouTube doing at the annual Game Developers Conference in San Francisco? Talking about integration with video games, obviously. More specifically, the company is hoping to expand an idea we first noticed in Call of Duty: Black Ops 2, whereby users could easily stream in-game content to YouTube. Clearly, the company worked in concert with Activision to make that possible, but forthcoming APIs will enable game developers far and wide to add the same functionality to other titles. Unfortunately, details remain murky regarding availability, but we are told that these new tools won't be limited to just consoles -- it sounds as if PC and mobile games will too be able to take advantage.

Filed under: Internet, Google

Comments

Source: The Slanted, CNET

Source: http://www.engadget.com/2013/03/28/youtube-video-game-streaming-api-gdc-2013/

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AMD Delivers Unified Gaming Strategy at GDC 2013

- AMD launches powerful cloud gaming platform AMD Radeon Sky Series graphics, extends "Never Settle: Reloaded" program with "BioShock Infinite" and showcases sneak peek of new "Ruby" demo -

SAN FRANCISCO - Mar. 26, 2013 - Today at the Game Developers Conference (GDC) AMD (NYSE: AMD) unveiled its leadership strategy for the worldwide gaming market. AMD's Unified Gaming Strategy comprehensively addresses how AMD will drive the gaming market across consoles, cloud platforms, tablets and PCs. By working with the world's leading hardware and game developers, and by continuing to be a leader in the market by providing the most innovative graphics technologies, AMD is effectively positioned to drive the next revolution in gaming.

Gaming Evolved, launched three years ago at GDC, is at the core of the AMD Unified Gaming Strategy, and has been the driving force behind the revolutionary "Never Settle" gaming bundles and a major factor behind the adoption of powerful AMD engines in the latest nextgeneration gaming consoles. Building on this momentum, AMD today introduced AMD Radeon? Sky Graphics, the cornerstone of AMD's industry-leading cloud gaming platform.

"Real-time gaming through the cloud represents a significant opportunity and AMD is poised to lead in this vertical thanks to our extensive graphics hardware and software capabilities," said David Cummings, senior director, AMD Professional Graphics. "AMD is working closely with CiiNow,G-Cluster, Otoy and Ubitus to deliver exceptional AMD Radeon? gaming experiences to the cloud."

Built from the ground up on the AMD Graphics Core Next architecture, this best-in-class graphics technology will lead the way in performance and define cloud gaming experiences for gamers. By working with industry-leaders like CiiNow, G-Cluster, Otoy and Ubitus, AMD has developed flexible cloud gaming technology and designed a solution that enables game developers and service providers to deliver a world-class content experience to millions of gamers whether it's through PCs, tablets, Smart TVs or mobile devices. Powering this seamless experience is AMD RapidFire technology, enabling highly efficient and responsive game streaming.

Continued Momentum in Discrete Graphics Lineup
With the arrival of the AMD Radeon? HD 7790 graphics card last week, AMD continues to deliver outstanding graphics products. Based on the award-winning Graphics Core Next architecture, the AMD Radeon HD 7790 GPU was made for gamers looking to play the latest games, including Gaming Evolved titles such as Crysis 3 and Tomb Raider, at the right price point.

"We continue to innovate and push the boundaries of our discrete graphics products," said Matt Skynner, corporate vice president and general manager, AMD Graphics. "Gamers demand the best experience across all of our products and with the AMD Radeon HD 7790 GPU, they receive the latest AMD Radeon technology at a competitive price point."

Packing in AMD Eyefinity technology and the award-winning Graphics Core Next architecture, the AMD Radeon HD 7790 GPU also features an enhanced version of AMD PowerTune technology, which enables higher performance and immersive gameplay to gaming rigs. This latest addition to the AMD Radeon? HD 7000 series of graphics products is the ultimate choice for gamers looking to maximize their gaming experience in the USD$150 MSRP range. The AMD Radeon HD 7790 GPU is expected to be available from all AMD add-in-board partners during the first week of April.

Ruby: Rebooted, Reborn, Reloaded
GDC also marked the 10th anniversary of the launch of the original iconic AMD "Ruby" demo. To celebrate this milestone, AMD unveiled a sneak peek of its remodeled and reinvented Ruby, which was designed and developed by IllFonic, and harnesses the power of Crytek's CryEngine? 3 development engine. The latest AMD "Ruby" demo is still under production and is designed to highlight real-world gaming possibilities of AMD Radeon graphics technology. It will be unveiled to the world in the coming weeks.

BioShock Infinite: The Best of DirectX? 11
As part of the "Never Settle: Reloaded" bundle, AMD is proud to announce the arrival of "BioShock: Infinite." With DirectX 11 PC-exclusive features such as anti-aliasing, texture detail, texture filtering, dynamic shadows and more, AMD is empowering gamers to unleash the most realistic gaming experience. Each of these features were developed in close collaboration with Irrational Games and the AMD Gaming Evolved team, ensuring the best experience for PC gamers choosing AMD Radeon graphics cards.

"Fifteen years ago, Irrational Games got its start making PC games, and the PC gaming experience has always been near and dear to our hearts. Working with AMD allowed us to make the most of the DirectX 11-powered graphics," said, Chris Kline, technical director, Irrational Games.

About AMD
AMD (NYSE: AMD) is a semiconductor design innovator leading the next era of vivid digital experiences with its groundbreaking AMD Accelerated Processing Units (APUs) that power a wide range of computing devices. AMD's server computing products are focused on driving industry-leading cloud computing and virtualization environments. AMD's superior graphics technologies are found in a variety of solutions ranging from game consoles, PCs to supercomputers. For more information, visit www.amd.com.

Source: http://www.joystiq.com/2013/03/27/amd-announces-sky-graphics-as-part-of-cloud-gaming-strategy/

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Source: http://orlandpark.patch.com/articles/this-week-s-pet-fiona-a-3-year-old-people-dog

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LONDON (AP) ? The harsh spending cuts introduced by European governments to tackle their crippling debt problems have not only pitched the region into recession ? they are also being partly blamed for outbreaks of diseases not normally seen in Europe and a spike in suicides, according to new research.

Since the crisis first struck in 2008, state-run welfare and health services across Europe have seen their budgets cut, medical treatments rationed and unpopular measures such as hospital user fees introduced.

Those countries that have slashed public spending the hardest ? namely Greece, Spain and Portugal ? have fared the worst medically.

"Austerity measures haven't solved the economic problems and they have also created big health problems," said Martin McKee, a professor of European Public Health at the London School of Hygiene and Tropical Medicine, who led the research.

He said worsening health was driven not just by unemployment, but by the lack of a social welfare system to fall back on. "People need to have hope that the government will help them through this difficult time," he said.

The paper was published online Wednesday in a special series of the journal Lancet.

McKee said Greece in particular was struggling. Based on government data, he and colleagues found suicides rose by 40 percent in 2011 compared to the previous year. Last year, the country also reported an exponential rise in the number of HIV cases among drug users, due in part to addicts sharing contaminated syringes after needle exchange programs were dropped.

In recent years, Greece has also battled outbreaks of malaria, West Nile virus and dengue fever.

"These are not diseases we would normally expect to see in Europe," said Willem de Jonge, general director of Medecins Sans Frontieres in Greece.

In 2011, MSF helped Greece tackle a malaria outbreak that broke out after authorities scrapped spraying programs to kill mosquitoes.

"There's a strong willingness in the government to respond (to health problems) but the problem is a lack of resources," de Jonge said.

Outside Madrid's Hospital Clinico San Carlos, several patients grumbled about deteriorating medical care.

"The cutbacks are noticeable in many ways," said Mari Carmen Cervera, 54, an unemployed nurse. Cervera's mother was initially admitted to the hospital with a serious heart problem that required surgery. Cervera says her mother was discharged too early and had to be brought back when she had trouble breathing one night.

"While she was (hospitalized), she wasn't being properly washed by the nursing staff, so I had to do it myself," she said. "I personally think what has happened to my mother is a consequence of negligence and I am going to make an official complaint as soon as (she) is well enough to come home again."

Hans Kluge of the World Health Organization's European office, advised countries against radical health reforms during an economic crisis. "In every health system, there is fat to cut," he said, recommending countries start with straightforward measures such as buying more generic drugs or eliminating unnecessary hospital beds.

Still, McKee and colleagues found not all countries mired in debt are unhealthy. Despite massive losses in its banking sector, Iceland rejected a bailout deal prescribed by the International Monetary Fund. McKee and colleagues didn't find any bump in suicides and the population may even be healthier since it nearly went bankrupt ? which could have been a result of global junk food chains pulling out of the country due to rising food costs.

Elsewhere, the researchers noted a drop in road accidents as more drivers opted for public transport. In turn, that has led to a shortage of organ donations and transplants, particularly in Spain and Ireland.

___

AP Writer Harold Heckle in Madrid contributed to this report.

Associated Press

Source: http://hosted2.ap.org/apdefault/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-26-EU-MED-Financial-Crisis-Health/id-677afb7f3d1b4fc6b71a314c9270d319

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Source: http://www.nbcnews.com/video/cnbc/51334123/

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Editor?s note: Sid Venkatesan is an IP partner specializing in high stakes IP disputes and IP counseling for technology companies in the Silicon Valley office of Orrick, Herrington & Sutcliffe LLP.?James Freedman?is an associate in Orrick?s IP group and a recent Stanford Law School graduate.?

Online content providers and aggregators are well aware of the potential penalties that can result from a copyright infringement lawsuit. In addition to being expensive to litigate, a copyright lawsuit can result in statutory damages (which can range between $750 to $30,000 for each infringing work found on a website), some or all of an infringer?s profits and even steeper penalties for willful infringement. A peer-to-peer platform relying on user-uploaded content, for example, can face nearly unlimited liability under this regime. Clearly, a copyright suit can have a crippling effect on an early-stage tech company.

One of Congress? goals when it passed the Digital Millennium Copyright Act in 1998 was to insulate certain digital content providers (called ?service providers? in the statute) as long as they promptly took down infringing works on notice from the copyright holder of those works.

Multi-part safe statutory tests are often a litigator?s delight, but they do not always provide clarity for businesses trying to comply with the law.

This protection is called a ?safe harbor? and can be used as a defense to a copyright infringement claim. There are several safe harbors in the DMCA (they are contained in Title 17 of the United States Code, Section 512). One important one, set forth in Section 512, subpart (c), protects service providers that offer ?storage at the direction of a user? on the provider?s network, i.e. a platform for user-uploaded content. These service providers can rely on the safe harbor as long as they:

Promptly take down allegedly infringing material upon receipt of a statutory compliant notice;
Do not have ?actual knowledge? of copyright infringement;
Are unaware of ?facts or circumstances from which infringing activity is apparent? (this is called ?red flag? knowledge in case law);
Remove or disable access to infringing material upon learning about it (whether or not a takedown notice has been received);
And do not receive a ?financial benefit directly attributable to the infringing activity? where the ?service provider has the right and ability to control the activity.

Multi-part safe statutory tests are often a litigator?s delight, but they do not always provide clarity for businesses trying to comply with the law. Indeed, Section 512(c) raises a number of questions. For example, what are ?facts and circumstances from which infringing activity is apparent?? Does an online ad-supported content-hosting platform ?receive financial benefit directly attributable to the infringing activity?? Does a service provider that processes or tags user-uploaded content perform ?storage at the direct of a user? or something else?

Unpacking Safe Harbor

The boundaries of the safe harbor have been tested in litigation and as a result, some recent federal Court of Appeals decisions have cleared up some of the questions around Section 512(c). Most recently, the Ninth Circuit Court of Appeals ? which covers nine states, including the west coast ? ruled that the video streaming site Veoh was protected by the safe harbor in a case brought by Universal Music Group (though Veoh?s successor won, the original company went bankrupt following a fire sale in 2010).

The reasoning of the Ninth Circuit was aligned with a 2012 decision in the Second Circuit (which covers Connecticut, New York and Vermont) in Viacom v. YouTube, meaning there is agreement as to some of the rules of the road for courts covering the largest media and technology hubs in the country.

Specifically, the Veoh and YouTube cases make clear that:

?Storage at the direction of a user? includes more than simply storing user-uploaded content. Veoh and YouTube both automatically processed uploaded videos for hosting and converted them to Flash. These activities were found to be protected as they were logically related to ?storage.? On the other hand, YouTube?s alleged practice of syndicating clips to third parties might not fall within the safe harbor, and this issue was sent back to the trial court for further litigation.
Neither ?actual knowledge? nor ?red flag? knowledge can be based on a general awareness that infringing works may be on the service provider?s system. For example, there were news articles in 2007 indicating that Veoh had been lax in policing infringing code, but the Ninth Circuit found that such general awareness was not tied to the allegedly infringing UMG works at issue in the case.?In reaching this conclusion,?the Ninth Circuit appeared to rely on Veoh?s policy of promptly taking down infringing content on notice and the absence of internal emails or documents showing that Veoh knew of specific infringing works on its system.
There is no affirmative duty by the service provider to continuously monitor for potentially infringing copyrighted material. This conclusion is consistent with the statutory notice and takedown scheme, which places the burden of identifying infringing material on the copyright holders.
That being said, a service provider is not allowed to simply sit back and wait for a takedown notice if it is aware of specifically infringing material. Some emails presented in the YouTube case suggested that the YouTube founders may have been aware that infringing material on the site yet elected to wait for a takedown notice before removing the material. This was one of the reasons the YouTube case was sent back to the trial court for further proceedings, whereas Veoh had obtained a summary judgment victory [the lesson here as always: bad evidence can rarely be covered up with legal doctrine]. Also, on Thursday, the Ninth Circuit concluded that the BitTorrent site isoHunt was not entitled to safe harbor protection because its operator ?actively encourag[ed] infringement,? including by ?urging his users to both upload and download? works, actions that showed he had at least red flag knowledge of infringing works.
Finally, the safe harbor does not apply where a service provider receives a financial benefit where the provider ?exerts substantial influence on the activities of the users.? Veoh?s model of letting users decide what should be uploaded and retaining the right to take down content in its discretion was found to not ?exert substantial influence on its users? and therefore fell within the safe harbor.

Generally, these cases show that a platform that leaves content uploads to the discretion of its users, performs processing specifically related to the display of and access to that content, promptly abides by DMCA takedown requests, and does not close its eyes to specifically infringing works can probably take comfort from Section 512(c).

Less clear is how business models that use user uploaded content for purposes other than general ad-supported storage and viewing or models that limit or direct what users upload will fare. Moreover, though affirmative monitoring is not required under these cases, we can reasonably expect that what constitutes ?red flag? knowledge may change over time as technology improves and service providers are more easily able to identify and analyze content on their platforms.

[This column reflects Sid?s and James? general views and does not constitute legal advice or the views of Orrick or its clients.]

[Image: Shutterstock]

Source: http://techcrunch.com/2013/03/24/some-rules-of-the-road-for-user-uploaded-content-platforms/

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Current and past smokers face greater risk for hip replacement failure

Public release date: 20-Mar-2013
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Contact: Lauren Pearson Riley
pearson@aaos.org
708-227-1773
American Academy of Orthopaedic Surgeons

CHICAGO Smoking has been linked to prolonged healing time and greater risk for complications in orthopaedic and other surgeries, according to a new study presented today at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).

Researchers reviewed records of all total hip replacement (THR, or total hip arthroplasty) patients between 2007 and 2009 to identify patients who used tobacco products at the time of surgery, or who smoked regularly prior to surgery.

There were 110 patients who regularly smoked, with a mean age of 55 and a mean follow up of 46 months following THR. A control group was matched 2:1 with the smoking group based on gender, date of surgery within six months, age within five years, related medical conditions (co-morbidities) and immunosuppressive conditions. The smoking group was categorized as current or former smokers, and according to the number of packs of cigarettes smoked per year.

At the most recent follow up, the patients who smoked had a 92 percent survival rate compared to 99 percent for non smokers. Of the nine THR revisions in smokers, four were done to alleviate pain and/or to repair a loose acetabular component (the hip socket), and five resulted from infection. Of the current smokers, six of 65 had revisions (9.2 percent); of the former smokers, 2 out of 45 patients (4.4 percent).

Overall, the patients who smoked had a higher overall revision rate and a higher incidence of other complications. The study authors recommend smoking cessation programs for all patients considering THR.

###

Learn more: AAOS.org

Learn more about AAOS at http://www.aaos.org.

Follow us on Facebook.com/AAOS1 and Twitter.com/AAOS1

A Nation in Motion
More than one in four Americans have bone or joint health problems, making them the greatest cause of lost work days in the U.S. When orthopaedic surgeons restore mobility and reduce pain, they help people get back to work and to independent, productive lives. Orthopaedic surgeons provide a great value, in both human and economic terms; and access to high-quality orthopaedic care keeps this "Nation in Motion." To learn more, to read hundreds of patient stories or to submit your own story, visit ANationinMotion.org.

For more information on bone and joint health, visit Orthoinfo.org.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Current and past smokers face greater risk for hip replacement failure Public release date: 20-Mar-2013
[ | E-mail | Share ]
Contact: Lauren Pearson Riley
pearson@aaos.org
708-227-1773
American Academy of Orthopaedic Surgeons

CHICAGO Smoking has been linked to prolonged healing time and greater risk for complications in orthopaedic and other surgeries, according to a new study presented today at the 2013 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).

Researchers reviewed records of all total hip replacement (THR, or total hip arthroplasty) patients between 2007 and 2009 to identify patients who used tobacco products at the time of surgery, or who smoked regularly prior to surgery.

There were 110 patients who regularly smoked, with a mean age of 55 and a mean follow up of 46 months following THR. A control group was matched 2:1 with the smoking group based on gender, date of surgery within six months, age within five years, related medical conditions (co-morbidities) and immunosuppressive conditions. The smoking group was categorized as current or former smokers, and according to the number of packs of cigarettes smoked per year.

At the most recent follow up, the patients who smoked had a 92 percent survival rate compared to 99 percent for non smokers. Of the nine THR revisions in smokers, four were done to alleviate pain and/or to repair a loose acetabular component (the hip socket), and five resulted from infection. Of the current smokers, six of 65 had revisions (9.2 percent); of the former smokers, 2 out of 45 patients (4.4 percent).

Overall, the patients who smoked had a higher overall revision rate and a higher incidence of other complications. The study authors recommend smoking cessation programs for all patients considering THR.

###

Learn more: AAOS.org

Learn more about AAOS at http://www.aaos.org.

Follow us on Facebook.com/AAOS1 and Twitter.com/AAOS1

A Nation in Motion
More than one in four Americans have bone or joint health problems, making them the greatest cause of lost work days in the U.S. When orthopaedic surgeons restore mobility and reduce pain, they help people get back to work and to independent, productive lives. Orthopaedic surgeons provide a great value, in both human and economic terms; and access to high-quality orthopaedic care keeps this "Nation in Motion." To learn more, to read hundreds of patient stories or to submit your own story, visit ANationinMotion.org.

For more information on bone and joint health, visit Orthoinfo.org.

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/aaoo-cap031813.php
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This process has been happening for a long time, but for those in finance, the value of Twitter is increasingly equaling or surpassing the value of traditional sell-side research from Wall Street analysts.

This weekend's surprise bailout of Cyprus (surprise, because of the fact that depositors in Cypriot banks are seeing a 'one-off' tax) is a major moment in the evolution of financial information.

Because the news was so surprising, and because there's so little time between when the bailout was announced early Saturday morning, and when trading begins Sunday evening, there's been an aggressive thirst for information and analysis on what it all means.

But the sell-side has been fairly slow, and the Twittersphere has come to the rescue.

The man everyone is reading is the pseudonymous twitterer @pawelmorski, who has written two must-read posts already on the Cypriot bailout. The first is here, and the second is here.

In the second one he writes:

After a surprisingly long gap, the verdicts from the Investment Bank research departments are dripping in. In short if you can sell euros at Friday?s close you probably should (you can?t ? pre-pre-market at 6pm London or 7am Auckland is about a percent off) but the tone is one of wariness rather than panic. The absence of Street research interest probably tells a bigger story than what they actually say. Only Barclays bothered with the Sunday conference call, but we?ll probably get more chances to dial in and be told that the research houses don?t really know what?s going on. We can also enjoy the spectacle of people who right now couldn?t name him interpret the importance of the intervention of Archbishop Chrysostomos. Not for the first time, Twitter was ahead of expensive analysts in concern about deposit haircuts.

Among the few analysts who have put out stuff this weekend are SocGen's Kit Juckes and Sebastien Galy, currency experts who both happen to be on Twitter, and are extremely plugged into the pace of demand for information.

In his latest email blast, SocGen's Kit Juckes basically tells trader clients to go read blogs and tweets:

There are links to three (critical) analyses of the move below, from the FT?s Alphaville blog, from the Schumpeter blog in the Economist and from the ?tweeter? Pawelmorski. I think they are the three best summations of the response of market respondents over the weekend.

http://ftalphaville.ft.com/2013/03/16/1425732/a-stupid-idea-whose-time-had-come/ ?http://www.economist.com/blogs/schumpeter/2013/03/cyprus-bail-out ? http://pawelmorski.wordpress.com/2013/03/16/cyprus-a-brutal-lesson-in-realpolitik-2/

That is pretty cool.

Other journalists noted the same thing, how fully Twitter dominated traditional research shops.

As for why it took so long to get reading material, another pseudonymous market pro basically just chalked it up to good old fashioned lack of knowledge on the subject.

And this is why Twitter is so killer.

In a very unusual crisis, the local knowledge was key. So it was essential to follow someone like Yiannis Mouzakis (to get the reaction from the Cyprus street) or Nick Malkouzis and Efthimia Efthimiou for the Greek perspective.

Bottom line: The value of Twitter (and Twitterers' blogs) have been growing for some time.

But on a weekend, with a high degree of local knowledge and nuance required, the best information out there was all free.

Now go read Pawelmorski's full post here >

Source: http://feedproxy.google.com/~r/typepad/alleyinsider/silicon_alley_insider/~3/NsT7hidhffo/twitter-beats-the-sell-side-after-cyprus-bailout-2013-3

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FILE - In this June 18, 1949 file photo, Ruth Steinhagen, 19, held in the shooting of Philadelphia Phillies first baseman Eddie Waitkus at a Chicago hotel on June 14, 1949, writes notes for her life history in Cook County Jail in Chicago. At the table she has a photograph of Waitkus taken June 17 in the hospital where he was recovering from a bullet wound. Steinhagen died of natural causes at 83 in late December 2012. Her death is the final chapter in one of the most sensational and bizarre criminal cases in Chicago history that made headlines around the country. She was the inspiration for Bernard Malamud?s novel ?The Natural? and the 1984 movie starring Robert Redford. (AP Photo/File)

FILE - In this Feb. 27, 1950 file photo, Philadelphia Phillies first baseman Eddie Waitkus, right, shows scars resulting from an operation following his shooting in Chicago in 1949, to his roommate, outfielder Bill Nicholson, on a beach in Clearwater, Fla. Waitkus was working his way back into condition at the team's spring training camp in Clearwater. Waitkus had been shot by 19-year-old Ruth Steinhagen at a hotel in one of the most sensational and bizarre criminal cases in Chicago history that made headlines around the country. Steinhagen died of natural causes at 83 in late December 2012. She was the inspiration for Bernard Malamud?s novel ?The Natural? and the 1984 movie starring Robert Redford, a mysterious woman who lured a major league ballplayer she'd never met into a hotel room with a cryptic note and shot him. (AP Photo/File)

FILE - In this June 17, 1949 file photo, Philadelphia Phillies first baseman Eddie Waitkus smiles from his bed in Illinois Masonic Hospital in Chicago as his father, Stephen, holds up his arm for an attempted wave. Waitkus was shot and seriously wounded June 14 in a Chicago hotel by 19-year-old Ruth Steinhagen. Steinhagen died of natural causes at 83 in late December 2012. Her death is the final chapter in one of the most sensational and bizarre criminal cases in Chicago history that made headlines around the country. She was the inspiration for Bernard Malamud?s novel ?The Natural? and the 1984 movie starring Robert Redford. (AP Photo/File)

FILE - In this Aug. 19, 1949 file photo, Philadelphia Phillies first baseman Eddie Waitkus acknowledges the applause of fans at Shibe Park as he stands by gifts showered on him on "Eddie Waitkus Night" in Philadelphia. Waitkus was in uniform for the first time since he was shot, June 14, 1949, in a Chicago hotel by 19-year-old Ruth Steinhagen. Steinhagen died of natural causes at 83 in late December 2012. Her death is the final chapter in one of the most sensational and bizarre criminal cases in Chicago history that made headlines around the country. She was the inspiration for Bernard Malamud?s novel ?The Natural? and the 1984 movie starring Robert Redford. (AP Photo/File)

FILE - In this June 16, 1949 file photo, Ruth Steinhagen, 19, is seen at felony court in Chicago where she appeared for her hearing on charges of assault with intent to murder in the shooting of Philadelphia Phillies ball player Eddie Waitkus at a Chicago hotel on June 14, 1949. Steinhagen died of natural causes at 83 in late December 2012. Her death is the final chapter in one of the most sensational and bizarre criminal cases in Chicago history that made headlines around the country. She was the inspiration for Bernard Malamud?s novel ?The Natural? and the 1984 movie starring Robert Redford. (AP Photo/Charles Knoblock, File)

CHICAGO (AP) ? She inspired a novel and a movie starring Robert Redford when in 1949 she lured a major league ballplayer she'd never met into a hotel room with a cryptic note and shot him, nearly killing him.

After the headlines faded, Ruth Ann Steinhagen did something else just as surprising: She disappeared into obscurity, living a quiet life unnoticed in Chicago until now, more than a half century later, when news broke that she had died three months earlier.

The Cook County Medical Examiner's Office confirmed Friday that Steinhagen passed away of natural causes on Dec. 29, at the age of 83. First reported by the Chicago Tribune last week, her identity was a surprise even to the morgue employees who knew about the 1984 movie "The Natural," in which she was portrayed by actress Barbara Hershey.

"She chose to live in the shadows and she did a good job of it," John Theodore, an author who wrote a 2002 nonfiction book about the crime, wrote in an email Sunday.

The story, with its elements of obsession, mystery, insanity and a baseball star, made it part of both Chicago's colorful crime history and rich baseball lore.

The story began with what appeared to be just another young woman's crush on Eddie Waitkus, the Chicago Cubs' handsome first baseman. So complete was this crush that the teenager set a place for Waitkus, whom she'd never met, at the family dinner table. She turned her bedroom into a shrine to him, and put his photo under her pillow.

After the 1948 season, Waitkus was traded to the Philadelphia Phillies ? a fateful turn. "When he went to the Phillies, that's when she decided to kill him," Theodore said in an interview.

Steinhagen had her chance the next season, when the Phillies came to Chicago to play the Cubs at Wrigley Field. She checked into a room at the Edgewater Beach Hotel where he was staying and invited him to her room.

"We're not acquainted, but I have something of importance to speak to you about," she wrote in a note to him after a game at Wrigley on June 14, 1949.

It worked. Waitkus arrived at her room. After he sat down, Steinhagen walked to a closet, said, "I have a surprise for you," then turned with the rifle she had hidden there and shot him in the chest. Theodore wrote that she then knelt by his side and held his hand on her lap. She told a psychiatrist afterward about how she had dreamed of killing him and found it strange that she was now "holding him in my arms."

Newspapers devoured and trumpeted the lurid story of a 19-year-old baseball groupie, known in the parlance of the day as a "Baseball Annie." Among the sensational and probably staged photos was one showing Steinhagen writing in her journal at a table in her jail cell with a framed photograph of Waitkus propped nearby.

A judge determined she was insane and committed her to a mental hospital. She was released three years later, after doctors determined she had regained her sanity.

Details about the rest of her life are sketchy. She lived with her sister in a house just a few miles from the hotel where she shot Waitkus. A neighbor told Theodore that Steinhagen said she worked in an office for 35 years but never revealed her employer. And she made an effort to conceal her privacy, often refusing to answer the phone or come to the door when Theodore knocked.

Chris Gentner, a neighbor who used to help the Steinhagen sisters with chores, said he only found out who she was 15 years after they began living nearby.

"I found out through my ex-wife ? I'm not sure how she found out ? and I looked (Steinhagen) up online. And as soon as I saw (her photograph) online I said, 'That's her,'" Gentner said.

The 1984 movie was based on a novel by Bernard Malamud that was inspired by the story. Theodore's 2002 book was entitled "Baseball's Natural: The story of Eddie Waitkus."

Waitkus, who played the season after he was shot, helping the Phillies win the National League pennant, decided not to press charges in 1952 when Steinhagen was deemed sane. The trial would have likely made banner headlines ? particularly since Malamud's novel was released in 1952 ? so Watikus' decision almost certainly assisted Steinhagen's disappearance into obscurity.

He died in 1972, 12 years before Redford portrayed Roy Hobbs, the character inspired by Waitkus.

"He hardly ever talked to his family about Ruth," Theodore said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-17-Obit-Baseball%20Stalker/id-0a93f60e817545c281078d6e578255b7

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WPA Pool/Reuters

Jony Ive with the Duchess.

Last November, Apple changed its executive leadership when it ousted Scott Forstall, who led development of the iPhone from its inception, leaving the company.

A lot of people saw the management shake up as a sign that Apple was preparing for a major overhaul of iOS, the software that powers iPhones, iPads, and iPod Touches.

An iOS overhaul could be in the works, but if people are expecting it this year, they're probably going to be let down.

Forstall's role was split between two people: Jony Ive, who would oversee the look and feel of Apple's mobile software, iOS, and Craig Federighi, who would lead the other aspects of the software.

With Forstall out, a lot of people started excitedly speculating about how iOS would change. One of the biggest complaints about Apple's software from the tech press was that it was larded with excessively detailed graphics.

Steve Jobs preferred making apps that looked like their real life counterpart. For instance, the notes app looks like a legal pad, complete with fake ripped sheets at the top. After Jobs died, Forstall continued this legacy in apps like Podcasts which had a fake tape machine running in the background.

Crisp lines and minimalism define Ive's hardware design. The assumption is that Ive will bring that same vision for clean design to iOS and wipe out some of the gaudy excess of Forstall.

This could happen, but if Ive is going to change iOS, it's going to take time. Apple can't rejigger iOS in six months.

Speaking on John Gruber's podcast last week, Guy English, an iOS developer who is friendly with people at Apple said that he knew iOS 7 wasn't going to be radically different. He warned that it wasn't based on inside information, but rather years of experience in product development.

"Just the way product planning works and time lines, there's no way they're rebooting all of iOS 7 after Forstall left," he said. "Maybe iOS 8 will be interesting, but iOS 7 will be less of a leap than many people are hoping for."

Gruber, one the smartest bloggers on Apple, said the same thing: "A lot of people expect iOS 7 to be new, new, new, and they're going to be disappointed, disappointed, disappointed."

If Apple has ideas for changing iOS significantly, look for them in 2014.

Source: http://www.businessinsider.com/apples-ios-7-wont-be-a-major-overhaul-2013-3

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Dimitri Albino is the proudly self-proclaimed smARtMAKER #1, and he's brought his company's Insert Coin finalist, the smARtPULSE oximeter, here to Expand. Using photodetection tech to produce readings of oxygen levels and pulse. While this is standard functionality, the company claims its advantage is in being able to cheaply deliver the product, and stream the data via Bluetooth to a computer or mobile device. It plans to offer both Bluetooth 2.0 and 4.0 versions of the product, and envisions them being accessible to individuals and other makers who want to build this kind of data into their projects thanks to its open communications protocol. Check below for a few pics of the current mock up and after the break for a video, although the production design is still being finalized.

Gallery: smARtPULSE Bluetooth oximeter

Follow all of Engadget's Expand coverage live from San Francisco right here!

Filed under: Peripherals, Wireless

Comments

Source: Project: smARtPULSE

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/RpapdUi5rQI/

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Mar. 12, 2013 ? New research from Boston University School of Medicine (BUSM) reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms. The study, published in the Proceedings of the National Academy of Sciences, indicates the importance of continuing to explore B cells as a therapeutic target to treat these diseases. Barbara Nikolajczyk, PhD, associate professor of microbiology at BUSM, is the study's senior author.

The incidence of diabetes continues to rise at alarming rates. According to the National Institute of Diabetes and Digestive and Kidney Diseases, the disease now affects approximately 25.8 million Americans. In 2007, the National Institutes of Health estimated that the direct and indirect costs of diabetes were a staggering $174 billion.

Type 2 diabetes, which is a common result of obesity, occurs when the body produces insulin but cannot use it properly (insulin resistance) or the body does not produce enough insulin. The body needs insulin to absorb glucose and generate energy. If the body does not produce and respond to insulin appropriately, it can, over time, lead to various complications such as cardiovascular disease, nerve damage, kidney disease and blindness.

Previous research has shown that B cells, which are white blood cells of the immune system, promote inflammation and can lead to the development of type 2 diabetes, but the mechanisms underlying B cell function were unclear.

The results of this study shed light on that question and indicate that B cells secrete a pro-inflammatory ratio of proteins called cytokines, which directly promote the insulin resistance that characterizes type 2 diabetes. The researchers also demonstrated that B cells directly regulate inflammatory T cells, an immune cell type known to cause insulin resistance in animal models of disease.

"Now that we have identified the specific mechanisms by which B cells promote inflammation, we can help develop novel, targeted approaches to treat type 2 diabetes," said Nikolajczyk. "Our study supports the continued exploration of FDA-approved B cell depletion drugs, which are known to be generally safe and effective, as novel agents to prevent obesity-associated inflammation and type 2 diabetes."

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Story Source:

The above story is reprinted from materials provided by Boston University Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

J. DeFuria, A. C. Belkina, M. Jagannathan-Bogdan, J. Snyder-Cappione, J. D. Carr, Y. R. Nersesova, D. Markham, K. J. Strissel, A. A. Watkins, M. Zhu, J. Allen, J. Bouchard, G. Toraldo, R. Jasuja, M. S. Obin, M. E. McDonnell, C. Apovian, G. V. Denis, B. S. Nikolajczyk. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1215840110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/lZ2pwRARX44/130312134744.htm

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Did you remember to set your clock forward on Sunday? Of course, it doesn?t really matter since most of us operate on digital devices like our smartphones that do the one-hour adjustment automatically. But the annual switch to Daylight Savings Time reportedly continues to be a costly endeavor, resulting in a net loss of $433,982,548 [...]

Source: http://news.yahoo.com/photos/mars-in-the-utah-desert-slideshow/

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Renewed Harvard-BASF initiative to advance functional materials

Public release date: 11-Mar-2013
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Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

Multi-university research will focus on innovative materials for the automotive, building and construction, and energy sectors

Cambridge, Mass. March 11, 2013 BASF SE, Harvard University, the Massachusetts Institute of Technology (MIT), and the University of Massachusetts (UMass) Amherst have established a research initiative called the "North American Center for Research on Advanced Materials."

A major goal of this initiative is to jointly develop new materials for the automotive, building and construction, and energy industries. The cooperation is initially planned for five years, during which time approximately 20 new postdoctoral positions will be created at the three universities.

"We are thrilled to be a part of this multidisciplinary, multi-institutional endeavor, which will connect and amplify Harvard's strengths in advanced materials research," said Cherry A. Murray, Dean of the Harvard School of Engineering and Applied Sciences. "The agreement reinforces our commitment to the pursuit of cutting-edge research targeted at high-impact areas of application."

Scientists and engineers from several disciplines such as chemistry, physics, and biology will collaborate in this research initiative. The academic partners contribute not only their expertise in materials science, modeling, and formulation methods, but also offer interesting, new approaches to conducting research. Besides fundamental scientific knowledge, BASF researchers will contribute the necessary experience in transforming research results into technically feasible processes and products. In addition, they will provide input about which materials are needed in different industries and applications.

The ideas and topics to be researched will be decided jointly by the researchers participating in the initiative. Topics already identified include micro- and nanostructured polymers with new properties, as well as bioinspired materials. The scientists are working on lightweight construction materials for wind turbines and automotive construction, for example, and on new color effects for cosmetic applications.

The new, multi-university initiative builds on the successful model pioneered by the BASF Advanced Research Initiative that was based at Harvard SEAS from October 2007 to present. Established with leadership from Harvard's Office of Technology Development, that initiative engaged 13 academic research groups across the University and resulted in significant advances in the study of biofilms and of chemical formulations for drugs, foods, and cosmetics.

"Our relationship with BASF provides us with many excellent scientific problems that are both intellectually challenging and relevant to real-world needs," said SEAS faculty member David Weitz, Mallinckrodt Professor of Physics and Applied Physics at Harvard. "We're thrilled to continue this collaboration and have the opportunity to share insights across institutions in a new way. Anything that helps build interactions among the incredible talent in this region is good for all of us."

Weitz will serve on a scientific advisory committee along with George Whitesides, Woodford L. and Ann A. Flowers University Professor at Harvard; Robert Langer and Mary Boyce at MIT; and Todd Emrick and Alan Lesser at UMass Amherst, along with BASF scientists.

"We need the creative spirit of the widest possible range of sciences to develop solutions to meet the needs of a growing world population for clean drinking water, secure energy supply, and improved quality of life," said Christian Fischer, President of BASF's Advanced Materials and Systems Research. "I am convinced that BASF's market-oriented materials and systems researchers, together with the outstanding scientists at the American universities, make up the ideal team for seeking out technically and economically viable solutions."

###

About the Harvard School of Engineering and Applied Sciences

Harvard School of Engineering and Applied Sciences serves as the connector and integrator of Harvard's teaching and research efforts in engineering, applied sciences, and technology. Through collaboration with researchers from all parts of Harvard, other universities, and corporate and foundational partners, we bring discovery and innovation directly to bear on improving human life and society. For more information, visit http://seas.harvard.edu.

About the Harvard Office of Technology Development

The Harvard Office of Technology Development (OTD) provides a one-stop shop to advance the development of groundbreaking discoveries by fostering strategic collaborations with industry through licensing, sponsored research and new venture agreements. OTD's mission is to make the fruits of Harvard research more accessible outside the University, including underserved communities, and ensure that society benefits from Harvard innovations by fostering their swift, professional and effective development and commercialization. Visit http://otd.harvard.edu.

About BASF

BASF Corporation, headquartered in Florham Park, New Jersey, is the North American affiliate of BASF SE, Ludwigshafen, Germany. BASF has more than 16,900 employees in North America, and had sales of $18.7 billion in 2012. For more information about BASF's North American operations, visit http://www.basf.us.

BASF is the world's leading chemical company: The Chemical Company. Its portfolio ranges from chemicals, plastics, performance products and crop protection products to oil and gas. We combine economic success with environmental protection and social responsibility. Through science and innovation, we enable our customers in nearly every industry to meet the current and future needs of society. Our products and solutions contribute to conserving resources, ensuring nutrition and improving quality of life. We have summed up this contribution in our corporate purpose: We create chemistry for a sustainable future. BASF posted sales of 78.7 billion in 2012 and had more than 113,000 employees as of the end of the year. BASF shares are traded on the stock exchanges in Frankfurt (BAS), London (BFA) and Zurich (AN). Further information on BASF is available on the Internet at http://www.basf.com.

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